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In a few studies colchicine-treated patients survived significantly longer than control patients {26} {27} {29} {31}. However, the high risk of toxicity associated with intravenous administration of colchicine must be considered {04} {09}. Colchicine also inhibits urate crystal deposition, which is enhanced by a low pH in the tissues, probably by inhibiting oxidation of glucose and subsequent lactic acid production in leukocytes {01} {02} {03}. Caution and careful attention to dosage are recommended to prevent accumulation and toxicity if colchicine is administered to these patients {05} {10}. However, after renal transplantation, prophylactic colchicine prevents amyloid deposition and resultant tissue damage in the transplanted kidney {13}.

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