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Methotrexate is in the following drug classes: antimetabolites, antipsoriatics, antirheumatics. I will say, though, that at one time they hoped to wean me off of the Methotrexate, but I started having flare-ups and the time between infusions was increased. Methotrexate is used to treat the following conditions: Acute Lymphoblastic Leukemia, Acute Lymphocytic Leukemia, Acute Nonlymphocytic Leukemia, Bladder Cancer, Brain Tumor, Breast Cancer, Bullous Pemphigoid, Cervical Cancer, Choriocarcinoma, Cogan's Syndrome, Colorectal Cancer, Dermatomyositis, Ectopic Pregnancy, Esophageal Carcinoma, Gastric Cancer, Head and Neck Cancer, Hodgkin's Lymphoma, Lymphoma, Meningeal Leukemia, Mycosis Fungoides, Neoplastic Diseases, Non-Hodgkin's Lymphoma, Non-Small Cell Lung Cancer, Osteosarcoma, Ovarian Cancer, Pancreatic Cancer, Pemphigoid, Pemphigus, Psoriasis, Rheumatoid Arthritis, Small Cell Lung Cancer, Soft Tissue Sarcoma, Solid Tumors, Systemic Sclerosis, Trophoblastic Disease. The proposed mechanism is PPI inhibition of the active tubular secretion of MTX and 7-hydroxymethotrexate via renal H+/K+ ATPase pumps. I'M HOPING TO GET OFF THE PREDNIOSE AND SEE HOW THE METHOTREXATE WILL WORK ALONE.
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