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Colchicine has permitted withdrawal of corticosteroid therapy in some patients with this condition {36} {37} {38}. However, the high risk of toxicity associated with intravenous administration of colchicine must be considered {04} {09}. Therapeutic doses of colchicine should be reserved for patients in whom these other agents are contraindicated or ineffective {05}. However, after renal transplantation, prophylactic colchicine prevents amyloid deposition and resultant tissue damage in the transplanted kidney {13}. If you are already taking Colchicine/Probenecid , you may continue to take it during a gout attack unless your doctor tells you otherwise. {01} {02} {03} {04} {05} {06} {07} Prophylactic administration of colchicine may be especially important during the first several months of treatment with an antihyperuricemic agent (allopurinol, probenecid, or sulfinpyrazone) because the frequency of acute attacks may be increased when such therapy is initiated.
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